abstract：:Bacterial infection remains a leading cause of mortality and morbidity for patients with cirrhosis, with hospitalization, alterations in the intestinal microbiota, and therapeutic drugs all implicated in its development. Bacterial infections also remain the most common precipitant of acute-on-chronic liver failure, wi...

journal_title：Digestive diseases and sciences

authors： Cannon MD,Martin P,Carrion AF

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Endoscopic submucosal dissection (ESD) criteria are histologically categorized by early gastric cancer (EGC) with differentiated- and undifferentiated-type histology. However, EGC is histologically heterogenous and there have been no separate criteria for EGC with mixed-type histology [EGC-MH; differentiated...

journal_title：Digestive diseases and sciences

authors： Bang CS,Yang YJ,Lee JJ,Baik GH

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Data on alcohol-related HCC are limited. AIMS:Our aim was to describe the incidence, management, and prognosis of alcohol compared to Hepatitis C (HCV)-related HCC at a national level. METHODS:Incident cases of HCC were identified in French healthcare databases between 2009 and 2012 and analyzed retrospect...

journal_title：Digestive diseases and sciences

authors： Costentin CE,Sogni P,Falissard B,Barbare JC,Bendersky N,Farges O,Goutte N

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND AIMS:To determine the value of contrast-enhanced endoscopic ultrasound (CE-EUS) for differentiation of pancreatic cystic neoplasms (PCNs). METHODS:From April 2015 to December 2017, 82 patients were enrolled in this study. All patients were confirmed to have PCNs by surgical pathology. Prior to surgery, ...

journal_title：Digestive diseases and sciences

authors： Zhong L,Chai N,Linghu E,Li H,Yang J,Tang P

更新日期：2019-12-01 00:00:00

abstract：AIM:Renal toxicity of adefovir disoproxil (ADV) and tenofovir disoproxil fumarate (TDF) is a significant concern in chronic hepatitis B (CHB) patients. Early observational clinical data suggested that telbivudine (LdT) might have renoprotective effects. METHODS:In this prospective study, consecutive CHB patients on co...

journal_title：Digestive diseases and sciences

authors： Mak LY,Liu SH,Yap DY,Seto WK,Wong DK,Fung J,Chan TM,Lai CL,Yuen MF

更新日期：2019-12-01 00:00:00

abstract：:Nonalcoholic steatohepatitis is the fastest-growing indication for the liver transplant and a leading cause of hepatocellular carcinoma among patients listed for liver transplantation in the USA. Post-transplant nonalcoholic hepatic steatosis and steatohepatitis are frequent complications of liver transplantation. Non...

journal_title：Digestive diseases and sciences

authors： Samji NS,Verma R,Keri KC,Singal AK,Ahmed A,Rinella M,Bernstein D,Abdelmalek MF,Satapathy SK

更新日期：2019-12-01 00:00:00

abstract：:This article [1] is retracted at the request of Editor-in-Chief. ...

journal_title：Digestive diseases and sciences

authors： Zong G,Xu Z,Zhang S,Shen Y,Qiu H,Zhu G,He S,Tao T,Chen X

更新日期：2019-11-11 00:00:00

abstract：INTRODUCTION:Crohn's disease (CD) follows a relapsing and remitting course incurring cumulative bowel damage over time. The question of whether or not the timing of the initiating biologic therapy affects long-term disease progression remains unanswered. Herein, we calculated rates of change in the Lémann index-which q...

journal_title：Digestive diseases and sciences

authors： Panchal H,Wagner M,Chatterji M,Taouli B,McBride R,Patterson JR,Ungaro R,Dubinsky M,Cho J,Sachar DB

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Hypoxia is an important factor in malignant tumors, and glycolysis is a major metabolic contributor in their development. Glycolytic enzymes have gained increasing attention as potential therapeutic targets because they are associated with cancer-specific metabolism. Fructose-bisphosphate aldolase A (ALDOA),...

journal_title：Digestive diseases and sciences

authors： Li X,Jiang F,Ge Z,Chen B,Yu J,Xin M,Wang J,An L,Wei J,Wu L

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:The endoscopic detection of esophageal cancer is suboptimal in both patients referred with dyspeptic symptoms and those enrolled in Barrett's surveillance programs. MCM5 expression in cells collected from gastric fluid may be correlated with the presence of dysplasia or adenocarcinoma. Analysis of this bioma...

journal_title：Digestive diseases and sciences

authors： Everson M,Magee C,Alzoubaidi D,Brogden S,Graham D,Lovat LB,Novelli M,Haidry R

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Double-balloon enteroscopy (DBE) is a safe and useful procedure for managing small bowel bleeding. However, there are limited studies regarding the preferable timing of DBE and its impact on long-term outcomes. AIM:We aimed to evaluate the association between the timing of DBE and the long-term outcomes of ...

journal_title：Digestive diseases and sciences

authors： Hashimoto R,Nakahori M,Matsuda T

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:MicroRNA is essential for the malignant progression of human gastric cancer (GC), which is a leading cause of cancer deaths. However, the mechanism is still not so clear. AIMS:In our present research, we investigated the effect of miR-9-5p in GC. METHODS:We detected miR-9-5p expression in human gastric epi...

journal_title：Digestive diseases and sciences

authors： Fan Y,Shi Y,Lin Z,Huang X,Li J,Huang W,Shen D,Zhuang G,Liu W

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:There are many studies on submucosal injection materials, but their clinical use is restricted for various reasons. The objective of this study was to compare the feasibility and safety of injected EndoClot®SIS polysaccharide as a submucosal injection material (SFC) in ESD in the pig stomach to that of injec...

journal_title：Digestive diseases and sciences

authors： Dai MS,Hu KW,Wu W,Yin GJ,Hu DM

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:Stent placement in the distal duodenum can be difficult. We describe a case report of a 94-year-old man with metastatic pancreatic head cancer compressing the third and fourth portions of the duodenum, treated by endoscopic stent placement using a colonoscope. AREAS COVERED:A literature review highlighted...

journal_title：Digestive diseases and sciences

authors： Minervini A,Lauro A,Pagano N,Vaccari S,D'Andrea V,Marino IR,Cervellera M,Tonini V

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Wnt ligand binding initiates the interaction between Frizzled and Dvl proteins. However, the regulation of Frizzled-Dvl proteins interaction remains largely unknown. AIMS:The present study aims to elucidate the regulation of Frizzled-Dvl interaction by WDR34. METHODS:The protein levels of WDR34 in hepatoce...

journal_title：Digestive diseases and sciences

authors： Luo X,Liu Y,Ma S,Liu L,Xie R,Wang S

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:The colon is partly controlled by myenteric and submucosal plexuses, which respond to stress and lead to some gastrointestinal disorders. These plexuses play roles in irritable bowel syndrome. Patients suffering from this syndrome can be treated with some antidepressants, including sertraline and nortriptyli...

journal_title：Digestive diseases and sciences

authors： Noorafshan A,Yousefi M,Hosseini L,Karbalay-Doust S

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Postmenopausal women have a higher risk of nonalcoholic steatohepatitis (NASH) along with an increase in age, and vitamin D deficiency occurs in some patients with NASH. AIM:We performed ovariectomy (OVX) surgery on female mice to mimic menopause, fed them a choline-deficient high-fat (CDHF) diet to induce ...

journal_title：Digestive diseases and sciences

authors： Ma L,Ishigami M,Honda T,Yokoyama S,Yamamoto K,Ishizu Y,Kuzuya T,Hayashi K,Hirooka Y,Goto H

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Fibromyalgia (FM) is a disorder characterized by widespread chronic pain as core symptom and a broad range of comorbidities. Despite the prevalence of gastrointestinal (GI) comorbidities in patients with FM, GI functions have rarely been investigated in animal models of FM. AIMS:The purpose of the present s...

journal_title：Digestive diseases and sciences

authors： Uchida M,Kobayashi O,Yoshida M,Miwa M,Miura R,Saito H,Nagakura Y

更新日期：2019-09-01 00:00:00

abstract：:In cases of difficult biliary cannulation, transpancreatic sphincterotomy (TPS) can be an alternative approach of biliary access. However, its success and safety profile have not been studied in detail. A systematic review and meta-analysis were performed to study the overall cannulation success and adverse events of ...

journal_title：Digestive diseases and sciences

authors： Pécsi D,Farkas N,Hegyi P,Varjú P,Szakács Z,Fábián A,Varga G,Rakonczay Z Jr,Bálint ER,Erőss B,Czimmer J,Szepes Z,Vincze Á

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Acute variceal bleeding (AVB) in patients with cirrhosis is associated with high mortality, ranging from 12 to 20% at 6 weeks. The existing prognostic models for AVB lack precision and require further validation. AIM:In this prospective study, we aimed to develop and validate a new prognostic model for AVB,...

journal_title：Digestive diseases and sciences

authors： Rout G,Sharma S,Gunjan D,Kedia S,Saraya A,Nayak B,Singh V,Kumar R,Shalimar

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Current guidelines recommend starting colorectal cancer (CRC) surveillance 8-10 years after inflammatory bowel disease (IBD) onset. Recent studies report that the incidence of CRC within 8-10 years of IBD onset (i.e., early CRC) ranges from 12 to 42%. AIMS:To describe the current prevalence of early CRC in ...

journal_title：Digestive diseases and sciences

authors： Cohen-Mekelburg S,Schneider Y,Gold S,Ghosh G,Rosenblatt R,Hajifathalian K,Scherl E,Schnoll-Sussman F,Katz P,Steinlauf A

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Intestinal failure is the most critical complication of Crohn's disease. Intestinal failure requires home parenteral nutrition, which worsens the quality of life of the patients and sometimes causes life-threatening complications. AIMS:The purpose of this study was to investigate the incidence and risk fact...

journal_title：Digestive diseases and sciences

authors： Watanabe Y,Miyoshi N,Fujino S,Takahashi H,Haraguchi N,Hata T,Matsuda C,Yamamoto H,Doki Y,Mori M,Mizushima T

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Biliary cannulation failure is a major problem during endoscopic retrograde cholangiopancreatography. It remains unclear how duodenal papilla morphology affects biliary cannulation. Therefore, we proposed a new classification system for the duodenal papilla based on oral protrusion pattern (ratio of the leng...

journal_title：Digestive diseases and sciences

authors： Watanabe M,Okuwaki K,Kida M,Imaizumi H,Yamauchi H,Kaneko T,Iwai T,Hasegawa R,Miyata E,Masutani H,Tadehara M,Adachi K,Koizumi W

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:HIV progression is characterized by immune activation and microbial translocation from the gut. Short-chain fatty acids (SCFAs) are essential for gut homeostasis. Decreased intestinal SCFAs play a role in rapid HIV progression. AIMS:To compare the SCFA profile, intestinal microbiome, and intestinal mucosal ...

journal_title：Digestive diseases and sciences

authors： Qing Y,Xie H,Su C,Wang Y,Yu Q,Pang Q,Cui F

更新日期：2019-07-01 00:00:00

abstract：:The original version of the article unfortunately contained an error in article title. The corrected title is 'Fecal Microbiota Transplantation Capsules with Targeted Colonic Versus Gastric Delivery in Recurrent Clostridium difficile Infection: A Comparative Cohort Analysis of High and Low Dose'. ...

journal_title：Digestive diseases and sciences

authors： Allegretti JR,Fischer M,Sagi SV,Bohm ME,Fadda HM,Ranmal SR,Budree S,Basit AW,Glettig DL,de la Serna EL,Gentile A,Gerardin Y,Timberlake S,Sadovsky R,Smith M,Kassam Z

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Preclinical data demonstrate that activation of the renin-angiotensin system (RAS) contributes to mucosal inflammation, and RAS inhibition by angiotensin-converting-enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) improves colitis in animal models. Less is known regarding the effects of RAS i...

journal_title：Digestive diseases and sciences

authors： Jacobs JD,Wagner T,Gulotta G,Liao C,Li YC,Bissonnette M,Pekow J

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Studies examining the mortality risk of inflammatory bowel disease (IBD) have yielded conflicting results, and most do not account for recent advancements made in the treatment of Crohn's disease (CD) and ulcerative colitis (UC). We aim to assess the overall, premature, and cause-specific mortality in IBD pa...

journal_title：Digestive diseases and sciences

authors： Nocerino A,Feathers A,Ivanina E,Durbin L,Swaminath A

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:A new prepared oral viscous budesonide (PVB) has been effective in inducing clinical and histological remission in pediatric eosinophilic esophagitis (EoE). AIMS:To evaluate the efficacy of a 12-week maintenance therapy on clinical, endoscopic, and histological remission using half of the dose used in the i...

journal_title：Digestive diseases and sciences

authors： Oliva S,Rossetti D,Papoff P,Tiberti A,Mallardo S,Volpe D,Ruggiero C,Russo G,Vezzoli D,Isoldi S,Cucchiara S

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Metabolic syndrome contributing to nonalcoholic fatty liver disease (NAFLD) can lead to hepatic dysfunction, steatohepatitis, cirrhosis, and hepatocellular carcinoma. AIMS:In this study, we tested whether diet-induced fatty liver in a mouse model physiologically mimicked human NAFLD, and whether transcripti...

journal_title：Digestive diseases and sciences

authors： Almanza D,Gharaee-Kermani M,Zhilin-Roth A,Rodriguez-Nieves JA,Colaneri C,Riley T,Macoska JA

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Mast cells (MCs), PAR2 and TRPV1, play a key role in the regulation of visceral pain. Several studies have found that probiotics regulate visceral sensitivity. AIMS:The purpose of the current study was to explore the role of MC-PAR2-TRPV1 in VH and the mechanism of VSL#3 in a rat model of VH. METHODS:A tot...

journal_title：Digestive diseases and sciences

authors： Li YJ,Dai C,Jiang M

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Bloating is one of the most bothersome symptoms of irritable bowel syndrome (IBS), but its association with other symptoms is not well described. AIMS:We investigated the association between symptoms of abdominal bloating, other IBS symptoms, psychological distress, and comorbid pain conditions. METHODS:We...

journal_title：Digestive diseases and sciences

authors： Hod K,Ringel Y,van Tilburg MAL,Ringel-Kulka T

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:Periampullary diverticulum (PAD) is most often asymptomatically found in elderly population. ERCP in the presence of PAD is technically challenging since the location and orientation of the ampulla could be altered. Various studies have reported differing results on the technical success and safety outcome...

journal_title：Digestive diseases and sciences

authors： Jayaraj M,Mohan BP,Dhindsa BS,Mashiana HS,Radhakrishnan G,Dhir V,Trindade AJ,Adler DG

更新日期：2019-05-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) arises from a number of cirrhosis-related and non-cirrhosis-related exposures and is one of the leading causes of cancer-related deaths worldwide. Achieving a durable cure currently relies on either resection or transplantation, but since most patients will be diagnosed with inoperable d...

journal_title：Digestive diseases and sciences

authors： Saffo S,Taddei TH

更新日期：2019-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) as an indication to liver transplant (LT) started as palliative treatment, then moved to potentially curative anti-cancer therapy and more recently entered the era of competition with non-cancer indications, consequent to the need of the society to target equal distribution of the limite...

journal_title：Digestive diseases and sciences

authors： Sposito C,Cucchetti A,Mazzaferro V

更新日期：2019-04-01 00:00:00

abstract：:With the increasing incidence of hepatocellular carcinoma (HCC) and its high mortality rates, effective treatment options are of urgent need, preferably in a multidisciplinary setting. In the management of those patients, interventional radiologists play a key role. In this article, we reviewed the current literature ...

journal_title：Digestive diseases and sciences

authors： Vogl TJ,Gruber-Rouh T

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:The role of 5-aminosalicylic acid (5-ASA or mesalamine) in the prevention of colorectal cancer in ulcerative colitis (UC) patients was reported, but the effect on molecular targets in UC colon mucosa is unknown. AIM:This observational study evaluates gene expression levels of 5-ASA targets using serial colo...

journal_title：Digestive diseases and sciences

authors： Bajpai M,Seril DN,Van Gurp J,Geng X,Alvarez J,Minacapelli CD,Gorin S,Das KK,Poplin E,Cheng J,Amenta PS,Das KM

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:MELD attempts to objectively predict the risk of mortality of patients with liver cirrhosis and is commonly used to prioritize organ allocation. Despite the usefulness of the MELD, updated metrics could further improve the accuracy of estimates of survival. AIMS:To assess and compare the prognostic ability ...

journal_title：Digestive diseases and sciences

authors： Jara M,Dziodzio T,Malinowski M,Lüttgert K,Nikolov R,Ritschl PV,Öllinger R,Pratschke J,Stockmann M

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) screening is cost-effective and prevents death from CRC if used appropriately. Physicians do not recommend CRC screening according to guidelines. Physician-related factors associated with CRC screening knowledge are unknown. AIMS:We tested the accuracy of CRC screening knowledge in a...

journal_title：Digestive diseases and sciences

authors： Patell R,Karwa A,Lopez R,Burke CA

更新日期：2019-02-01 00:00:00

abstract：INTRODUCTION:The impact of antithrombotic treatment on the findings of small-bowel capsule endoscopy for patients with obscure gastrointestinal bleeding remains contentious. We aimed to determine the effect of these agents on small-bowel video capsule endoscopy positive findings. METHODS:MEDLINE, Cochrane Library, and...

journal_title：Digestive diseases and sciences

authors： Tziatzios G,Gkolfakis P,Papanikolaou IS,Triantafyllou K

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Liver fibrosis can progress to cirrhosis, hepatocellular carcinoma, or liver failure. Unfortunately, the antifibrotic agents are limited. Thrombin activates hepatic stellate cells (HSCs). Therefore, we investigated the effects of a direct thrombin inhibitor, dabigatran, on liver fibrosis. METHODS:Adult male...

journal_title：Digestive diseases and sciences

authors： Lee KC,Hsu WF,Hsieh YC,Chan CC,Yang YY,Huang YH,Hou MC,Lin HC

更新日期：2019-01-01 00:00:00